Emergency Medicine is Hard

Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock

https://pubmed.ncbi.nlm.nih.gov/36972033/

Conclusions and relevance: In this comparative effectiveness cohort study among adult patients with septic shock who began hydrocortisone treatment, the addition of fludrocortisone was associated with increased hospital survival, shorter length of stay, and decreased shock duration compared with hydrocortisone alone

Hydrocortisone in Severe Community-Acquired Pneumonia

https://www.nejm.org/doi/full/10.1056/NEJMoa2215145

Conclusions and relevance: Among patients with severe community-acquired pneumonia being treated in the ICU, those who received hydrocortisone had a lower risk of death by day 28 than those who received placebo.